T-DOT (Toronto Disparities, Overdose and Treatment) is an ongoing cohort study that started in 2018 (formerly OiSIS) of people who use drugs, looking at supervised consumption sites, drug checking, treatment, and the continuum of care. Sub-studies include: Injectable Opioid Agonist Treatment (iOAT) and Safer Opioid Supply (SOS or Prescribed Alternatives) program evaluations in Toronto.

The Policy Impact Unit works in partnership with drug policy stakeholders – including people who use drugs, affected communities, civil society, and policymakers – to support the development of evidence- and rights-based drug policies in Canada and around the globe.